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Thallium in PDB 1fpj: Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate, Thallium (10 Mm) and Lithium Ions (10 Mm)

Enzymatic activity of Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate, Thallium (10 Mm) and Lithium Ions (10 Mm)

All present enzymatic activity of Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate, Thallium (10 Mm) and Lithium Ions (10 Mm):
3.1.3.11;

Protein crystallography data

The structure of Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate, Thallium (10 Mm) and Lithium Ions (10 Mm), PDB code: 1fpj was solved by V.Villeret, W.N.Lipscomb, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 8.00 / 2.20
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 61.200, 166.800, 80.300, 90.00, 90.00, 90.00
R / Rfree (%) 18.9 / n/a

Thallium Binding Sites:

The binding sites of Thallium atom in the Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate, Thallium (10 Mm) and Lithium Ions (10 Mm) (pdb code 1fpj). This binding sites where shown within 5.0 Angstroms radius around Thallium atom.
In total 4 binding sites of Thallium where determined in the Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate, Thallium (10 Mm) and Lithium Ions (10 Mm), PDB code: 1fpj:
Jump to Thallium binding site number: 1; 2; 3; 4;

Thallium binding site 1 out of 4 in 1fpj

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Thallium binding site 1 out of 4 in the Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate, Thallium (10 Mm) and Lithium Ions (10 Mm)


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 1 of Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate, Thallium (10 Mm) and Lithium Ions (10 Mm) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Tl336

b:35.6
occ:0.63
OD1 A:ASP118 2.8 19.6 1.0
O A:LEU120 2.9 17.7 1.0
OE2 A:GLU97 2.9 51.2 1.0
OE2 A:GLU98 3.1 43.8 1.0
CD A:GLU97 3.3 44.1 1.0
OE1 A:GLU97 3.3 46.7 1.0
OG A:SER123 3.6 40.7 1.0
CG A:ASP118 3.8 20.5 1.0
C A:LEU120 3.8 17.9 1.0
O3P A:AHG339 3.9 47.2 1.0
OD2 A:ASP118 4.0 22.4 1.0
CA A:ASP121 4.3 19.4 1.0
CD A:GLU98 4.3 37.4 1.0
N A:ASP121 4.4 18.7 1.0
CG A:GLU97 4.5 38.4 1.0
N A:LEU120 4.6 17.7 1.0
CB A:GLU97 4.6 29.2 1.0
CB A:SER123 4.6 33.8 1.0
CA A:LEU120 4.7 19.9 1.0

Thallium binding site 2 out of 4 in 1fpj

Go back to Thallium Binding Sites List in 1fpj
Thallium binding site 2 out of 4 in the Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate, Thallium (10 Mm) and Lithium Ions (10 Mm)


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 2 of Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate, Thallium (10 Mm) and Lithium Ions (10 Mm) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Tl337

b:47.1
occ:0.50
OE2 A:GLU280 2.8 27.6 1.0
OE1 A:GLU280 3.0 25.2 1.0
NH1 A:ARG276 3.2 50.1 1.0
CD A:GLU280 3.3 23.9 1.0
O1 A:AHG339 3.9 40.2 1.0
OE2 A:GLU97 4.1 51.2 1.0
CD2 A:LEU275 4.1 14.0 1.0
O A:LYS274 4.1 21.4 1.0
C2 A:AHG339 4.3 27.8 1.0
CZ A:ARG276 4.3 51.6 1.0
C1 A:AHG339 4.4 31.4 1.0
CD A:ARG276 4.5 32.6 1.0
CA A:LEU275 4.6 17.5 1.0
OD1 A:ASP121 4.6 22.9 1.0
CG A:LYS274 4.7 22.6 1.0
CG A:GLU280 4.8 20.5 1.0
N A:ARG276 4.8 16.7 1.0
CE A:LYS274 4.8 25.4 1.0
C A:LYS274 4.8 20.7 1.0
NE A:ARG276 4.8 44.9 1.0
CD A:GLU97 4.9 44.1 1.0
NH1 A:ARG313 5.0 32.8 1.0

Thallium binding site 3 out of 4 in 1fpj

Go back to Thallium Binding Sites List in 1fpj
Thallium binding site 3 out of 4 in the Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate, Thallium (10 Mm) and Lithium Ions (10 Mm)


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 3 of Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate, Thallium (10 Mm) and Lithium Ions (10 Mm) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Tl336

b:38.8
occ:0.55
OD1 B:ASP118 2.8 23.9 1.0
O B:LEU120 2.9 17.9 1.0
OE2 B:GLU97 3.2 51.3 1.0
OE2 B:GLU98 3.3 55.1 1.0
OE1 B:GLU97 3.4 47.9 1.0
CD B:GLU97 3.5 44.7 1.0
C B:LEU120 3.7 16.7 1.0
CG B:ASP118 3.8 20.9 1.0
O1P B:AHG339 3.8 38.0 1.0
OD2 B:ASP118 4.0 25.7 1.0
OG B:SER123 4.1 37.3 1.0
CA B:ASP121 4.2 16.8 1.0
N B:ASP121 4.3 15.2 1.0
N B:LEU120 4.5 18.2 1.0
CD B:GLU98 4.5 50.3 1.0
CB B:SER123 4.6 30.7 1.0
CB B:GLU97 4.7 30.7 1.0
CA B:LEU120 4.7 17.4 1.0
CG B:GLU97 4.7 40.1 1.0

Thallium binding site 4 out of 4 in 1fpj

Go back to Thallium Binding Sites List in 1fpj
Thallium binding site 4 out of 4 in the Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate, Thallium (10 Mm) and Lithium Ions (10 Mm)


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 4 of Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate, Thallium (10 Mm) and Lithium Ions (10 Mm) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Tl337

b:50.3
occ:0.45
OE2 B:GLU280 2.8 25.2 1.0
OE1 B:GLU280 3.0 22.6 1.0
CD B:GLU280 3.3 20.4 1.0
NH1 B:ARG276 3.4 41.1 1.0
OE2 B:GLU97 3.7 51.3 1.0
O B:LYS274 4.1 19.5 1.0
O1 B:AHG339 4.2 36.7 1.0
CD2 B:LEU275 4.3 13.7 1.0
CD B:GLU97 4.4 44.7 1.0
CD B:ARG276 4.5 30.6 1.0
C2 B:AHG339 4.6 20.3 1.0
CA B:LEU275 4.6 19.3 1.0
CZ B:ARG276 4.6 43.8 1.0
C1 B:AHG339 4.6 27.4 1.0
CE B:LYS274 4.7 20.0 1.0
N B:ARG276 4.7 21.3 1.0
OD1 B:ASP121 4.7 22.8 1.0
CG B:GLU280 4.8 17.4 1.0
CG B:LYS274 4.8 20.6 1.0
C B:LYS274 4.9 20.1 1.0
NH1 B:ARG313 4.9 39.4 1.0
O1P B:AHG339 4.9 38.0 1.0
O3P B:AHG339 5.0 45.8 1.0

Reference:

V.Villeret, S.Huang, H.J.Fromm, W.N.Lipscomb. Crystallographic Evidence For the Action of Potassium, Thallium, and Lithium Ions on Fructose-1,6-Bisphosphatase. Proc.Natl.Acad.Sci.Usa V. 92 8916 1995.
ISSN: ISSN 0027-8424
PubMed: 7568043
DOI: 10.1073/PNAS.92.19.8916
Page generated: Wed Dec 16 02:28:32 2020

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