Atomistry » Thallium » PDB 1f1h-4wfh » 1fpl
Atomistry »
  Thallium »
    PDB 1f1h-4wfh »
      1fpl »

Thallium in PDB 1fpl: Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate and Thallium Ions (10 Mm)

Enzymatic activity of Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate and Thallium Ions (10 Mm)

All present enzymatic activity of Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate and Thallium Ions (10 Mm):
3.1.3.11;

Protein crystallography data

The structure of Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate and Thallium Ions (10 Mm), PDB code: 1fpl was solved by V.Villeret, W.N.Lipscomb, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 8.00 / 2.30
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 61.100, 166.900, 80.200, 90.00, 90.00, 90.00
R / Rfree (%) 19.4 / n/a

Thallium Binding Sites:

The binding sites of Thallium atom in the Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate and Thallium Ions (10 Mm) (pdb code 1fpl). This binding sites where shown within 5.0 Angstroms radius around Thallium atom.
In total 6 binding sites of Thallium where determined in the Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate and Thallium Ions (10 Mm), PDB code: 1fpl:
Jump to Thallium binding site number: 1; 2; 3; 4; 5; 6;

Thallium binding site 1 out of 6 in 1fpl

Go back to Thallium Binding Sites List in 1fpl
Thallium binding site 1 out of 6 in the Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate and Thallium Ions (10 Mm)


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 1 of Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate and Thallium Ions (10 Mm) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Tl336

b:45.7
occ:0.43
 OD1 A:ASP121 2.5 22.7 1.0
OD2 A:ASP118 2.6 31.7 1.0
OE1 A:GLU97 2.6 46.3 1.0
OE2 A:GLU280 2.6 34.5 1.0
O3P A:AHG340 2.9 47.6 1.0
OE2 A:GLU97 3.2 49.6 1.0
CD A:GLU97 3.2 44.1 1.0
TL A:TL338 3.4 39.2 0.6
CG A:ASP118 3.5 27.8 1.0
CG A:ASP121 3.6 26.5 1.0
O2P A:AHG340 3.6 47.1 1.0
P1 A:AHG340 3.7 48.2 1.0
OD1 A:ASP118 3.8 27.8 1.0
CD A:GLU280 3.8 31.3 1.0
TL A:TL337 3.9 43.7 0.7
O1 A:AHG340 4.1 41.6 1.0
CA A:ASP121 4.1 26.4 1.0
CB A:ASP121 4.1 24.8 1.0
C1 A:AHG340 4.1 31.6 1.0
OE1 A:GLU280 4.5 33.9 1.0
N A:GLY122 4.6 24.8 1.0
OD2 A:ASP121 4.7 21.4 1.0
CG A:GLU97 4.7 40.0 1.0
CG A:GLU280 4.8 27.5 1.0
C2 A:AHG340 4.8 28.1 1.0
CB A:ASP118 4.9 24.5 1.0
C A:ASP121 4.9 24.6 1.0

Thallium binding site 2 out of 6 in 1fpl

Go back to Thallium Binding Sites List in 1fpl
Thallium binding site 2 out of 6 in the Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate and Thallium Ions (10 Mm)


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 2 of Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate and Thallium Ions (10 Mm) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Tl337

b:43.7
occ:0.65
 OE2 A:GLU97 2.8 49.6 1.0
OE2 A:GLU98 2.9 43.4 1.0
O A:LEU120 2.9 22.1 1.0
OD1 A:ASP118 3.0 27.8 1.0
OG A:SER123 3.4 49.2 1.0
CD A:GLU97 3.5 44.1 1.0
TL A:TL336 3.9 45.7 0.4
C A:LEU120 3.9 23.5 1.0
OE1 A:GLU97 4.0 46.3 1.0
CG A:ASP118 4.0 27.8 1.0
CD A:GLU98 4.1 37.7 1.0
O3P A:AHG340 4.2 47.6 1.0
OD2 A:ASP118 4.3 31.7 1.0
CG A:GLU97 4.4 40.0 1.0
CA A:ASP121 4.5 26.4 1.0
N A:ASP121 4.6 24.7 1.0
CB A:SER123 4.6 44.1 1.0
N A:LEU120 4.6 22.7 1.0
CB A:GLU97 4.7 32.2 1.0
CA A:LEU120 4.8 24.6 1.0
OE1 A:GLU98 4.9 37.9 1.0
CG A:GLU98 5.0 35.7 1.0

Thallium binding site 3 out of 6 in 1fpl

Go back to Thallium Binding Sites List in 1fpl
Thallium binding site 3 out of 6 in the Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate and Thallium Ions (10 Mm)


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 3 of Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate and Thallium Ions (10 Mm) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Tl338

b:39.2
occ:0.55
 OE1 A:GLU280 3.2 33.9 1.0
OE2 A:GLU280 3.3 34.5 1.0
NH1 A:ARG276 3.3 58.1 1.0
TL A:TL336 3.4 45.7 0.4
CD A:GLU280 3.6 31.3 1.0
OE1 A:GLU97 3.8 46.3 1.0
O2P A:AHG340 3.9 47.1 1.0
O A:LYS274 4.0 23.3 1.0
CD A:ARG276 4.1 38.9 1.0
O1 A:AHG340 4.4 41.6 1.0
CD A:GLU97 4.4 44.1 1.0
CZ A:ARG276 4.4 54.2 1.0
OE2 A:GLU97 4.5 49.6 1.0
CD2 A:LEU275 4.5 16.6 1.0
CA A:LEU275 4.6 20.4 1.0
N A:ARG276 4.6 23.7 1.0
NE A:ARG276 4.7 47.5 1.0
P1 A:AHG340 4.7 48.2 1.0
NH1 A:ARG313 4.7 48.6 1.0
C2 A:AHG340 4.7 28.1 1.0
CG A:LYS274 4.8 22.5 1.0
C A:LYS274 4.8 23.3 1.0
C1 A:AHG340 4.9 31.6 1.0
OD1 A:ASP121 4.9 22.7 1.0
CE A:LYS274 5.0 20.6 1.0

Thallium binding site 4 out of 6 in 1fpl

Go back to Thallium Binding Sites List in 1fpl
Thallium binding site 4 out of 6 in the Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate and Thallium Ions (10 Mm)


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 4 of Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate and Thallium Ions (10 Mm) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Tl336

b:42.6
occ:0.42
 OE2 B:GLU280 2.5 28.5 1.0
OD2 B:ASP118 2.5 26.1 1.0
OD1 B:ASP121 2.6 20.6 1.0
OE1 B:GLU97 2.6 41.3 1.0
OE2 B:GLU97 3.0 45.5 1.0
O1P B:AHG340 3.1 36.8 1.0
CD B:GLU97 3.2 37.9 1.0
CG B:ASP118 3.4 21.5 1.0
TL B:TL338 3.4 40.8 0.5
CG B:ASP121 3.6 26.1 1.0
OD1 B:ASP118 3.6 24.8 1.0
CD B:GLU280 3.7 26.4 1.0
TL B:TL337 3.9 44.7 0.6
P1 B:AHG340 3.9 43.4 1.0
O3P B:AHG340 3.9 41.7 1.0
CB B:ASP121 4.1 22.2 1.0
O1 B:AHG340 4.1 32.5 1.0
CA B:ASP121 4.1 20.9 1.0
C1 B:AHG340 4.3 25.3 1.0
OE1 B:GLU280 4.4 30.8 1.0
N B:GLY122 4.6 24.2 1.0
CG B:GLU280 4.6 24.3 1.0
CG B:GLU97 4.6 35.1 1.0
OD2 B:ASP121 4.7 23.3 1.0
CB B:ASP118 4.8 15.8 1.0
C2 B:AHG340 4.9 21.5 1.0
C B:ASP121 4.9 22.0 1.0

Thallium binding site 5 out of 6 in 1fpl

Go back to Thallium Binding Sites List in 1fpl
Thallium binding site 5 out of 6 in the Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate and Thallium Ions (10 Mm)


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 5 of Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate and Thallium Ions (10 Mm) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Tl337

b:44.7
occ:0.64
 O B:LEU120 2.8 20.2 1.0
OD1 B:ASP118 3.0 24.8 1.0
OE2 B:GLU98 3.1 54.8 1.0
OE2 B:GLU97 3.2 45.5 1.0
CD B:GLU97 3.7 37.9 1.0
C B:LEU120 3.8 21.0 1.0
TL B:TL336 3.9 42.6 0.4
CG B:ASP118 4.0 21.5 1.0
OE1 B:GLU97 4.1 41.3 1.0
O1P B:AHG340 4.1 36.8 1.0
OG B:SER123 4.2 42.6 1.0
OD2 B:ASP118 4.3 26.1 1.0
CD B:GLU98 4.3 50.0 1.0
CG B:GLU97 4.4 35.1 1.0
CA B:ASP121 4.4 20.9 1.0
N B:ASP121 4.5 20.0 1.0
N B:LEU120 4.5 21.9 1.0
CB B:GLU97 4.6 30.2 1.0
CA B:LEU120 4.7 20.8 1.0
CB B:SER123 4.8 41.6 1.0
CG B:PRO119 5.0 17.8 1.0

Thallium binding site 6 out of 6 in 1fpl

Go back to Thallium Binding Sites List in 1fpl
Thallium binding site 6 out of 6 in the Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate and Thallium Ions (10 Mm)


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 6 of Fructose-1,6-Bisphosphatase (D-Fructose-1,6-Bisphosphate 1- Phosphohydrolase) Complexed with Amp, 2,5-Anhydro-D-Glucitol-1,6- Bisphosphate and Thallium Ions (10 Mm) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Tl338

b:40.8
occ:0.53
 NH1 B:ARG276 3.0 46.2 1.0
OE2 B:GLU280 3.1 28.5 1.0
OE1 B:GLU280 3.2 30.8 1.0
TL B:TL336 3.4 42.6 0.4
CD B:GLU280 3.6 26.4 1.0
O3P B:AHG340 3.9 41.7 1.0
OE1 B:GLU97 4.0 41.3 1.0
OE2 B:GLU97 4.1 45.5 1.0
O B:LYS274 4.1 24.1 1.0
CD B:ARG276 4.1 30.5 1.0
CZ B:ARG276 4.2 44.8 1.0
O1 B:AHG340 4.2 32.5 1.0
CD B:GLU97 4.3 37.9 1.0
CD2 B:LEU275 4.4 15.0 1.0
CA B:LEU275 4.5 21.9 1.0
P1 B:AHG340 4.6 43.4 1.0
NE B:ARG276 4.6 39.5 1.0
C2 B:AHG340 4.6 21.5 1.0
CG B:LYS274 4.7 29.7 1.0
CE B:LYS274 4.7 28.4 1.0
N B:ARG276 4.7 25.7 1.0
C B:LYS274 4.8 25.8 1.0
C1 B:AHG340 4.8 25.3 1.0
N B:LEU275 5.0 21.6 1.0
O1P B:AHG340 5.0 36.8 1.0
CD B:LYS274 5.0 28.6 1.0
OD1 B:ASP121 5.0 20.6 1.0

Reference:

V.Villeret, S.Huang, H.J.Fromm, W.N.Lipscomb. Crystallographic Evidence For the Action of Potassium, Thallium, and Lithium Ions on Fructose-1,6-Bisphosphatase. Proc.Natl.Acad.Sci.Usa V. 92 8916 1995.
ISSN: ISSN 0027-8424
PubMed: 7568043
DOI: 10.1073/PNAS.92.19.8916
Page generated: Fri Oct 11 09:15:57 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy