Atomistry » Thallium » PDB 1f1h-4wfh » 1lqo
Atomistry »
  Thallium »
    PDB 1f1h-4wfh »
      1lqo »

Thallium in PDB 1lqo: Crystal Strutcure of the Fosfomycin Resistance Protein A (Fosa) Containing Bound Thallium Cations

Enzymatic activity of Crystal Strutcure of the Fosfomycin Resistance Protein A (Fosa) Containing Bound Thallium Cations

All present enzymatic activity of Crystal Strutcure of the Fosfomycin Resistance Protein A (Fosa) Containing Bound Thallium Cations:
2.5.1.18;

Protein crystallography data

The structure of Crystal Strutcure of the Fosfomycin Resistance Protein A (Fosa) Containing Bound Thallium Cations, PDB code: 1lqo was solved by C.L.Rife, R.E.Pharris, M.E.Newcomer, R.N.Armstrong, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 2.00
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 55.797, 65.874, 76.958, 90.00, 90.00, 90.00
R / Rfree (%) 19.7 / 25.2

Other elements in 1lqo:

The structure of Crystal Strutcure of the Fosfomycin Resistance Protein A (Fosa) Containing Bound Thallium Cations also contains other interesting chemical elements:

Manganese (Mn) 2 atoms

Thallium Binding Sites:

The binding sites of Thallium atom in the Crystal Strutcure of the Fosfomycin Resistance Protein A (Fosa) Containing Bound Thallium Cations (pdb code 1lqo). This binding sites where shown within 5.0 Angstroms radius around Thallium atom.
In total 6 binding sites of Thallium where determined in the Crystal Strutcure of the Fosfomycin Resistance Protein A (Fosa) Containing Bound Thallium Cations, PDB code: 1lqo:
Jump to Thallium binding site number: 1; 2; 3; 4; 5; 6;

Thallium binding site 1 out of 6 in 1lqo

Go back to Thallium Binding Sites List in 1lqo
Thallium binding site 1 out of 6 in the Crystal Strutcure of the Fosfomycin Resistance Protein A (Fosa) Containing Bound Thallium Cations


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 1 of Crystal Strutcure of the Fosfomycin Resistance Protein A (Fosa) Containing Bound Thallium Cations within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Tl501

b:29.1
occ:0.50
O3 B:PO4201 2.4 42.7 1.0
O3 A:PO4202 2.5 33.6 1.0
O4 A:PO4202 2.8 28.5 1.0
NE2 A:HIS7 3.0 15.8 1.0
P A:PO4202 3.1 32.2 1.0
SG A:CYS48 3.3 30.5 1.0
CE1 A:HIS7 3.3 19.8 1.0
CD2 A:HIS7 3.3 19.3 1.0
P B:PO4201 3.4 41.9 1.0
CZ2 A:TRP46 3.5 25.2 1.0
CH2 A:TRP46 3.5 25.9 1.0
NH1 B:ARG119 3.7 29.3 1.0
O4 B:PO4201 3.7 39.3 1.0
ND1 A:HIS7 3.8 18.9 1.0
O2 A:PO4202 3.8 34.4 1.0
CG A:HIS7 3.8 19.6 1.0
MN B:MN401 3.8 26.9 1.0
O1 B:PO4201 4.1 39.8 1.0
O A:HOH753 4.2 30.5 1.0
CE2 A:TRP46 4.2 24.3 1.0
CZ3 A:TRP46 4.3 24.8 1.0
CE2 A:TYR39 4.3 29.9 1.0
CZ B:ARG119 4.4 33.0 1.0
O1 A:PO4202 4.5 31.8 1.0
NH2 B:ARG119 4.5 32.3 1.0
CB A:CYS48 4.5 24.1 1.0
O2 B:PO4201 4.6 47.7 1.0
OG1 A:THR9 4.7 20.1 1.0
OH A:TYR39 4.7 24.1 1.0
CZ A:TYR39 4.8 30.3 1.0
CB A:HIS7 4.8 21.0 1.0
NE1 A:TRP46 4.9 22.1 1.0
CD2 A:TRP46 4.9 25.3 1.0
CE3 A:TRP46 4.9 23.7 1.0

Thallium binding site 2 out of 6 in 1lqo

Go back to Thallium Binding Sites List in 1lqo
Thallium binding site 2 out of 6 in the Crystal Strutcure of the Fosfomycin Resistance Protein A (Fosa) Containing Bound Thallium Cations


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 2 of Crystal Strutcure of the Fosfomycin Resistance Protein A (Fosa) Containing Bound Thallium Cations within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Tl602

b:31.7
occ:0.70
O A:GLY96 2.6 24.6 1.0
OD1 A:ASN92 2.6 29.8 1.0
OG A:SER94 2.8 32.0 1.0
OG A:SER98 2.8 19.9 1.0
O A:GLU95 2.9 26.9 1.0
O A:SER94 3.1 28.5 1.0
CB A:SER98 3.5 19.7 1.0
C A:SER94 3.5 30.2 1.0
CG A:ASN92 3.5 29.9 1.0
CE1 A:HIS112 3.6 18.9 1.0
OH A:TYR100 3.6 26.3 1.0
O2 A:PO4301 3.7 40.3 1.0
ND1 A:HIS112 3.7 17.4 1.0
C A:GLU95 3.7 28.1 1.0
C A:GLY96 3.7 25.4 1.0
NH2 A:ARG119 3.8 24.5 1.0
ND2 A:ASN92 3.9 32.1 1.0
CB A:SER94 3.9 31.6 1.0
CA A:SER94 4.1 32.0 1.0
N A:SER94 4.1 33.2 1.0
N A:GLU95 4.3 29.0 1.0
O A:HOH767 4.3 25.6 1.0
N A:GLY96 4.4 26.6 1.0
CA A:GLY96 4.4 26.4 1.0
N A:SER98 4.4 21.6 1.0
C A:ASP97 4.5 22.3 1.0
OE2 A:GLU110 4.6 21.2 1.0
CA A:SER98 4.6 20.2 1.0
CA A:GLU95 4.6 28.0 1.0
O A:ASP97 4.7 19.1 1.0
NE2 A:HIS112 4.8 17.6 1.0
CZ A:TYR100 4.8 19.9 1.0
N A:ASP97 4.8 24.0 1.0
P A:PO4301 4.8 37.3 1.0
O4 A:PO4301 4.8 35.3 1.0
CB A:ASN92 4.9 28.0 1.0
CZ A:ARG119 5.0 30.6 1.0

Thallium binding site 3 out of 6 in 1lqo

Go back to Thallium Binding Sites List in 1lqo
Thallium binding site 3 out of 6 in the Crystal Strutcure of the Fosfomycin Resistance Protein A (Fosa) Containing Bound Thallium Cations


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 3 of Crystal Strutcure of the Fosfomycin Resistance Protein A (Fosa) Containing Bound Thallium Cations within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Tl701

b:53.4
occ:0.16
OG B:SER44 3.4 31.5 1.0
OG A:SER44 3.5 32.7 1.0
CB B:SER44 4.1 27.4 1.0
CB A:SER44 4.2 26.9 1.0

Thallium binding site 4 out of 6 in 1lqo

Go back to Thallium Binding Sites List in 1lqo
Thallium binding site 4 out of 6 in the Crystal Strutcure of the Fosfomycin Resistance Protein A (Fosa) Containing Bound Thallium Cations


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 4 of Crystal Strutcure of the Fosfomycin Resistance Protein A (Fosa) Containing Bound Thallium Cations within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Tl502

b:33.7
occ:0.70
OG B:SER94 2.4 30.2 1.0
OD1 B:ASN92 2.6 32.8 1.0
O B:SER94 2.8 31.4 1.0
O B:GLY96 2.8 32.8 1.0
OG B:SER98 2.9 18.5 1.0
O B:GLU95 3.0 28.4 1.0
C B:SER94 3.4 34.1 1.0
CB B:SER98 3.4 23.7 1.0
OH B:TYR100 3.5 32.6 1.0
CG B:ASN92 3.6 32.6 1.0
O4 B:PO4201 3.6 39.3 1.0
CB B:SER94 3.7 34.6 1.0
C B:GLU95 3.8 32.1 1.0
CE1 B:HIS112 3.8 23.6 1.0
NH2 B:ARG119 3.9 32.3 1.0
ND1 B:HIS112 3.9 23.6 1.0
ND2 B:ASN92 4.0 32.1 1.0
CA B:SER94 4.0 33.8 1.0
C B:GLY96 4.0 30.5 1.0
O2 B:PO4201 4.0 47.7 1.0
N B:SER94 4.1 35.5 1.0
N B:GLU95 4.2 33.0 1.0
O B:HOH755 4.4 31.6 1.0
N B:SER98 4.5 25.1 1.0
P B:PO4201 4.5 41.9 1.0
N B:GLY96 4.6 30.5 1.0
C B:ASP97 4.6 25.9 1.0
CA B:SER98 4.6 23.1 1.0
OE2 B:GLU110 4.6 20.2 1.0
CA B:GLU95 4.6 32.4 1.0
CZ B:TYR100 4.7 25.1 1.0
O B:ASP97 4.7 24.1 1.0
CA B:GLY96 4.7 31.2 1.0
CB B:ASN92 4.9 30.9 1.0
NE2 B:HIS112 5.0 21.1 1.0

Thallium binding site 5 out of 6 in 1lqo

Go back to Thallium Binding Sites List in 1lqo
Thallium binding site 5 out of 6 in the Crystal Strutcure of the Fosfomycin Resistance Protein A (Fosa) Containing Bound Thallium Cations


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 5 of Crystal Strutcure of the Fosfomycin Resistance Protein A (Fosa) Containing Bound Thallium Cations within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Tl601

b:28.4
occ:0.50
O1 A:PO4301 2.0 41.2 1.0
O1 A:PO4302 2.7 43.5 1.0
O2 A:PO4302 2.7 30.0 1.0
NE2 B:HIS7 3.1 22.8 1.0
CZ2 B:TRP46 3.2 26.4 1.0
P A:PO4301 3.2 37.3 1.0
P A:PO4302 3.3 36.5 1.0
CD2 B:HIS7 3.4 24.9 1.0
CH2 B:TRP46 3.4 22.7 1.0
CE1 B:HIS7 3.5 19.7 1.0
SG B:CYS48 3.6 29.8 0.5
O2 A:PO4301 3.6 40.3 1.0
NH1 A:ARG119 3.7 28.4 1.0
MN A:MN402 3.8 26.5 1.0
CG B:HIS7 3.9 19.5 1.0
ND1 B:HIS7 3.9 19.1 1.0
CE2 B:TRP46 4.0 24.4 1.0
O4 A:PO4302 4.1 42.9 1.0
O A:HOH749 4.2 35.1 1.0
O3 A:PO4301 4.2 31.1 1.0
O4 A:PO4301 4.2 35.3 1.0
CZ3 B:TRP46 4.2 22.6 1.0
CE2 B:TYR39 4.4 28.7 1.0
O3 A:PO4302 4.5 42.5 1.0
OG1 B:THR9 4.5 19.4 1.0
CZ A:ARG119 4.6 30.6 1.0
OH B:TYR39 4.6 29.8 1.0
NE1 B:TRP46 4.6 23.5 1.0
CB B:CYS48 4.7 23.5 0.5
CB B:CYS48 4.7 23.1 0.5
SG B:CYS48 4.7 32.3 0.5
CD2 B:TRP46 4.7 23.1 1.0
NH2 A:ARG119 4.8 24.5 1.0
CZ B:TYR39 4.8 29.5 1.0
CB B:HIS7 4.8 18.6 1.0
CE3 B:TRP46 4.8 22.3 1.0

Thallium binding site 6 out of 6 in 1lqo

Go back to Thallium Binding Sites List in 1lqo
Thallium binding site 6 out of 6 in the Crystal Strutcure of the Fosfomycin Resistance Protein A (Fosa) Containing Bound Thallium Cations


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 6 of Crystal Strutcure of the Fosfomycin Resistance Protein A (Fosa) Containing Bound Thallium Cations within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Tl702

b:46.1
occ:0.25
CZ B:TYR62 3.0 47.1 1.0
CE2 B:TYR62 3.0 46.7 1.0
CE1 B:TYR62 3.1 41.7 1.0
OG A:SER50 3.1 29.1 1.0
CD2 B:TYR62 3.1 43.2 1.0
CD1 B:TYR62 3.2 41.4 1.0
CG B:TYR62 3.3 35.0 1.0
O A:HOH759 3.5 42.1 1.0
OH B:TYR62 3.7 53.5 1.0
CB B:TYR62 4.3 27.3 1.0
CB A:SER50 4.5 27.6 1.0

Reference:

C.L.Rife, R.E.Pharris, M.E.Newcomer, R.N.Armstrong. Crystal Structure of A Genomically Encoded Fosfomycin Resistance Protein (Fosa) at 1.19 A Resolution By Mad Phasing Off the L-III Edge of Tl(+) J.Am.Chem.Soc. V. 124 11001 2002.
ISSN: ISSN 0002-7863
PubMed: 12224946
DOI: 10.1021/JA026879V
Page generated: Wed Dec 16 02:28:32 2020

Last articles

Zn in 7OQY
Zn in 7PEL
Zn in 7OYG
Zn in 7P3S
Zn in 7PE7
Zn in 7RZC
Zn in 7PE9
Zn in 7PE8
Zn in 7RAG
Zn in 7RN5
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy