Atomistry » Thallium » PDB 1f1h-4wfh » 4p1a
Atomistry »
  Thallium »
    PDB 1f1h-4wfh »
      4p1a »

Thallium in PDB 4p1a: Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph

Protein crystallography data

The structure of Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph, PDB code: 4p1a was solved by G.Verdon, O.Boudker, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 3.75
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 106.979, 196.564, 206.499, 90.00, 90.00, 90.00
R / Rfree (%) 23 / 25.7

Other elements in 4p1a:

The structure of Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph also contains other interesting chemical elements:

Mercury (Hg) 3 atoms

Thallium Binding Sites:

The binding sites of Thallium atom in the Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph (pdb code 4p1a). This binding sites where shown within 5.0 Angstroms radius around Thallium atom.
In total 6 binding sites of Thallium where determined in the Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph, PDB code: 4p1a:
Jump to Thallium binding site number: 1; 2; 3; 4; 5; 6;

Thallium binding site 1 out of 6 in 4p1a

Go back to Thallium Binding Sites List in 4p1a
Thallium binding site 1 out of 6 in the Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 1 of Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Tl501

b:0.1
occ:0.80
O A:THR308 2.7 1.0 1.0
O A:SER349 2.8 0.3 1.0
O A:ASN310 3.4 0.7 1.0
N A:GLY351 3.4 0.8 1.0
N A:THR352 3.5 0.7 1.0
C A:SER349 3.6 0.5 1.0
N A:ALA353 3.6 0.7 1.0
CA A:ILE350 3.6 0.4 1.0
C A:ILE309 3.7 0.1 1.0
O A:ILE309 3.7 0.9 1.0
C A:THR308 3.8 0.6 1.0
CA A:ILE309 3.9 0.9 1.0
CA A:ALA353 3.9 0.1 1.0
C A:ILE350 3.9 0.2 1.0
N A:ILE350 3.9 0.6 1.0
C A:ASN310 4.0 0.3 1.0
C A:THR352 4.0 0.5 1.0
OG A:SER349 4.0 0.8 1.0
CB A:ALA353 4.1 1.0 1.0
CA A:THR352 4.3 0.9 1.0
N A:ASN310 4.3 0.4 1.0
CG A:MET311 4.3 0.3 1.0
N A:ILE309 4.3 0.2 1.0
C A:GLY351 4.4 0.1 1.0
CA A:GLY351 4.4 0.9 1.0
CA A:MET311 4.5 0.6 1.0
OG1 A:THR352 4.5 0.6 1.0
N A:MET311 4.6 0.0 1.0
CB A:SER349 4.7 0.2 1.0
O A:THR352 4.7 0.5 1.0
CA A:SER349 4.8 0.0 1.0
CA A:ASN310 4.8 0.1 1.0
CB A:ILE350 4.8 0.1 1.0
CB A:THR352 4.9 0.8 1.0
CB A:MET311 5.0 0.8 1.0
OG1 A:THR314 5.0 0.2 1.0

Thallium binding site 2 out of 6 in 4p1a

Go back to Thallium Binding Sites List in 4p1a
Thallium binding site 2 out of 6 in the Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 2 of Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Tl502

b:0.2
occ:0.80
O A:VAL355 2.9 0.8 1.0
OD2 A:ASP394 2.9 0.9 1.0
O A:ARG276 2.9 0.5 1.0
OG1 A:THR398 2.9 0.5 1.0
O A:PRO356 3.2 0.7 1.0
NH2 A:ARG397 3.4 0.0 1.0
O A:ALA353 3.6 1.0 1.0
CZ A:ARG397 3.7 0.2 1.0
NH1 A:ARG397 3.8 0.3 1.0
CA A:GLY354 3.9 0.6 1.0
CG A:ASP394 4.0 0.8 1.0
C A:VAL355 4.0 0.5 1.0
C A:ARG276 4.1 0.6 1.0
C A:PRO356 4.1 0.7 1.0
CB A:THR398 4.1 0.8 1.0
CG2 A:THR398 4.3 0.6 1.0
O A:ASP394 4.3 0.5 1.0
CA A:PRO356 4.4 0.1 1.0
NE A:ARG397 4.5 0.2 1.0
OD1 A:ASP394 4.5 0.0 1.0
C A:ALA353 4.6 0.5 1.0
CA A:THR398 4.7 0.8 1.0
N A:PRO356 4.7 0.1 1.0
N A:THR398 4.7 0.7 1.0
CA A:ARG276 4.7 0.5 1.0
N A:GLY354 4.8 0.3 1.0
N A:ALA358 4.9 0.4 1.0
CB A:ARG276 4.9 0.4 1.0
CG1 A:VAL355 4.9 1.0 1.0

Thallium binding site 3 out of 6 in 4p1a

Go back to Thallium Binding Sites List in 4p1a
Thallium binding site 3 out of 6 in the Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 3 of Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Tl501

b:1.0
occ:0.80
O B:THR308 2.8 0.6 1.0
O B:SER349 3.1 0.9 1.0
O B:ASN310 3.5 0.7 1.0
N B:GLY351 3.6 0.6 1.0
CA B:ILE350 3.7 0.3 1.0
C B:ILE309 3.7 0.1 1.0
O B:ILE309 3.7 0.3 1.0
N B:ALA353 3.7 0.1 1.0
C B:SER349 3.7 0.3 1.0
N B:THR352 3.7 0.3 1.0
CA B:ILE309 3.9 0.5 1.0
C B:ASN310 3.9 1.0 1.0
C B:THR308 3.9 0.5 1.0
CA B:ALA353 4.0 0.4 1.0
OG B:SER349 4.0 0.3 1.0
N B:ILE350 4.0 0.2 1.0
CB B:ALA353 4.0 1.0 1.0
C B:ILE350 4.1 0.6 1.0
CG B:MET311 4.1 0.4 1.0
N B:ASN310 4.2 0.1 1.0
C B:THR352 4.2 0.1 1.0
CA B:MET311 4.2 0.2 1.0
N B:MET311 4.4 0.4 1.0
N B:ILE309 4.4 0.5 1.0
CA B:THR352 4.5 0.5 1.0
C B:GLY351 4.6 0.0 1.0
CA B:GLY351 4.6 0.6 1.0
CA B:ASN310 4.6 0.8 1.0
CB B:SER349 4.7 0.9 1.0
CB B:MET311 4.7 0.9 1.0
OG1 B:THR352 4.7 0.6 1.0
CB B:ILE350 4.8 0.8 1.0
CA B:SER349 4.8 0.9 1.0
OG1 B:THR314 4.9 0.2 1.0
O B:THR352 4.9 0.5 1.0

Thallium binding site 4 out of 6 in 4p1a

Go back to Thallium Binding Sites List in 4p1a
Thallium binding site 4 out of 6 in the Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 4 of Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Tl502

b:0.8
occ:0.80
OD2 B:ASP394 2.7 0.2 1.0
OG1 B:THR398 2.9 0.3 1.0
O B:ARG276 3.0 0.9 1.0
O B:VAL355 3.0 0.3 1.0
O B:PRO356 3.1 0.2 1.0
NH2 B:ARG397 3.4 0.7 1.0
CZ B:ARG397 3.6 0.2 1.0
NH1 B:ARG397 3.7 0.3 1.0
O B:ALA353 3.8 0.8 1.0
CG B:ASP394 3.9 1.0 1.0
CB B:THR398 4.1 0.1 1.0
C B:PRO356 4.1 0.8 1.0
CA B:GLY354 4.1 0.3 1.0
C B:ARG276 4.1 0.7 1.0
O B:ASP394 4.2 0.0 1.0
C B:VAL355 4.2 0.6 1.0
CG2 B:THR398 4.3 0.1 1.0
NE B:ARG397 4.4 0.6 1.0
OD1 B:ASP394 4.4 0.3 1.0
CA B:PRO356 4.5 0.1 1.0
CA B:THR398 4.6 0.4 1.0
N B:THR398 4.6 0.8 1.0
CA B:ARG276 4.8 0.2 1.0
C B:ALA353 4.8 0.2 1.0
N B:PRO356 4.8 0.1 1.0
CB B:ARG276 4.8 1.0 1.0
N B:ALA358 4.9 0.1 1.0
CB B:ASP394 5.0 0.7 1.0
N B:GLY354 5.0 0.3 1.0

Thallium binding site 5 out of 6 in 4p1a

Go back to Thallium Binding Sites List in 4p1a
Thallium binding site 5 out of 6 in the Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 5 of Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Tl501

b:0.4
occ:0.50
O C:SER349 2.9 0.9 1.0
O C:ASN310 3.1 0.7 1.0
O C:THR308 3.2 1.0 1.0
C C:SER349 3.6 0.7 1.0
N C:ALA353 3.7 0.6 1.0
OG C:SER349 3.7 0.4 1.0
O C:ILE309 3.7 0.8 1.0
C C:ASN310 3.7 0.8 1.0
CA C:ALA353 3.8 0.0 1.0
C C:ILE309 3.9 0.6 1.0
CA C:ILE350 3.9 0.2 1.0
N C:THR352 3.9 0.3 1.0
CA C:MET311 4.0 0.1 1.0
N C:GLY351 4.0 0.2 1.0
CB C:ALA353 4.0 0.5 1.0
CG C:MET311 4.1 0.4 1.0
N C:ILE350 4.1 0.1 1.0
C C:THR352 4.1 0.7 1.0
N C:MET311 4.2 0.8 1.0
CA C:ILE309 4.3 0.9 1.0
C C:THR308 4.3 0.3 1.0
N C:ASN310 4.4 0.5 1.0
OG1 C:THR314 4.4 0.3 1.0
C C:ILE350 4.4 1.0 1.0
CB C:SER349 4.5 0.9 1.0
CA C:THR352 4.5 1.0 1.0
CB C:MET311 4.6 0.7 1.0
OG1 C:THR352 4.6 0.9 1.0
CA C:ASN310 4.7 0.3 1.0
CA C:SER349 4.7 0.2 1.0
O C:THR352 4.8 0.3 1.0
N C:ILE309 4.8 0.9 1.0
C C:GLY351 4.9 0.4 1.0
CA C:GLY351 5.0 0.2 1.0

Thallium binding site 6 out of 6 in 4p1a

Go back to Thallium Binding Sites List in 4p1a
Thallium binding site 6 out of 6 in the Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 6 of Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Tl502

b:0.9
occ:0.50
OD2 C:ASP394 2.3 0.1 1.0
OG1 C:THR398 2.7 0.6 1.0
O C:PRO356 3.0 1.0 1.0
O C:ARG276 3.2 0.3 1.0
NH2 C:ARG397 3.2 0.7 1.0
O C:VAL355 3.4 0.1 1.0
CG C:ASP394 3.4 0.9 1.0
CZ C:ARG397 3.4 0.2 1.0
NH1 C:ARG397 3.6 0.1 1.0
O C:ASP394 3.7 0.7 1.0
CB C:THR398 4.0 0.2 1.0
OD1 C:ASP394 4.0 0.6 1.0
O C:ALA353 4.1 0.1 1.0
C C:PRO356 4.1 0.7 1.0
NE C:ARG397 4.1 0.7 1.0
C C:ARG276 4.3 0.0 1.0
N C:THR398 4.3 0.1 1.0
CG2 C:THR398 4.4 0.7 1.0
CA C:THR398 4.5 0.0 1.0
CB C:ASP394 4.5 0.1 1.0
C C:VAL355 4.6 1.0 1.0
CA C:GLY354 4.6 0.5 1.0
C C:ASP394 4.7 1.0 1.0
CB C:ARG397 4.7 0.5 1.0
CA C:PRO356 4.7 0.1 1.0
CB C:ARG276 4.7 0.1 1.0
CA C:ARG276 4.8 0.5 1.0
CA C:ASP394 4.8 0.5 1.0
N C:ALA358 4.9 0.7 1.0
CD C:ARG397 5.0 0.1 1.0

Reference:

G.Verdon, S.Oh, R.N.Serio, O.Boudker. Coupled Ion Binding and Structural Transitions Along the Transport Cycle of Glutamate Transporters. Elife V. 3 02283 2014.
ISSN: ESSN 2050-084X
PubMed: 24842876
DOI: 10.7554/ELIFE.02283
Page generated: Wed Dec 16 02:28:46 2020

Last articles

Sr in 3I55
Sr in 3G71
Sr in 3I5A
Sr in 3G6E
Sr in 3G4S
Sr in 3GOO
Sr in 3CPW
Sr in 3CME
Sr in 3CMA
Sr in 3EY3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy