Atomistry » Thallium » PDB 1f1h-4wfh » 4p1a
Atomistry »
  Thallium »
    PDB 1f1h-4wfh »
      4p1a »

Thallium in PDB 4p1a: Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph

Protein crystallography data

The structure of Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph, PDB code: 4p1a was solved by G.Verdon, O.Boudker, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 3.75
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 106.979, 196.564, 206.499, 90.00, 90.00, 90.00
R / Rfree (%) 23 / 25.7

Other elements in 4p1a:

The structure of Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph also contains other interesting chemical elements:

Mercury (Hg) 3 atoms

Thallium Binding Sites:

The binding sites of Thallium atom in the Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph (pdb code 4p1a). This binding sites where shown within 5.0 Angstroms radius around Thallium atom.
In total 6 binding sites of Thallium where determined in the Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph, PDB code: 4p1a:
Jump to Thallium binding site number: 1; 2; 3; 4; 5; 6;

Thallium binding site 1 out of 6 in 4p1a

Go back to Thallium Binding Sites List in 4p1a
Thallium binding site 1 out of 6 in the Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 1 of Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Tl501

b:0.1
occ:0.80
 O A:THR308 2.7 1.0 1.0
O A:SER349 2.8 0.3 1.0
O A:ASN310 3.4 0.7 1.0
N A:GLY351 3.4 0.8 1.0
N A:THR352 3.5 0.7 1.0
C A:SER349 3.6 0.5 1.0
N A:ALA353 3.6 0.7 1.0
CA A:ILE350 3.6 0.4 1.0
C A:ILE309 3.7 0.1 1.0
O A:ILE309 3.7 0.9 1.0
C A:THR308 3.8 0.6 1.0
CA A:ILE309 3.9 0.9 1.0
CA A:ALA353 3.9 0.1 1.0
C A:ILE350 3.9 0.2 1.0
N A:ILE350 3.9 0.6 1.0
C A:ASN310 4.0 0.3 1.0
C A:THR352 4.0 0.5 1.0
OG A:SER349 4.0 0.8 1.0
CB A:ALA353 4.1 1.0 1.0
CA A:THR352 4.3 0.9 1.0
N A:ASN310 4.3 0.4 1.0
CG A:MET311 4.3 0.3 1.0
N A:ILE309 4.3 0.2 1.0
C A:GLY351 4.4 0.1 1.0
CA A:GLY351 4.4 0.9 1.0
CA A:MET311 4.5 0.6 1.0
OG1 A:THR352 4.5 0.6 1.0
N A:MET311 4.6 0.0 1.0
CB A:SER349 4.7 0.2 1.0
O A:THR352 4.7 0.5 1.0
CA A:SER349 4.8 0.0 1.0
CA A:ASN310 4.8 0.1 1.0
CB A:ILE350 4.8 0.1 1.0
CB A:THR352 4.9 0.8 1.0
CB A:MET311 5.0 0.8 1.0
OG1 A:THR314 5.0 0.2 1.0

Thallium binding site 2 out of 6 in 4p1a

Go back to Thallium Binding Sites List in 4p1a
Thallium binding site 2 out of 6 in the Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 2 of Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Tl502

b:0.2
occ:0.80
 O A:VAL355 2.9 0.8 1.0
OD2 A:ASP394 2.9 0.9 1.0
O A:ARG276 2.9 0.5 1.0
OG1 A:THR398 2.9 0.5 1.0
O A:PRO356 3.2 0.7 1.0
NH2 A:ARG397 3.4 0.0 1.0
O A:ALA353 3.6 1.0 1.0
CZ A:ARG397 3.7 0.2 1.0
NH1 A:ARG397 3.8 0.3 1.0
CA A:GLY354 3.9 0.6 1.0
CG A:ASP394 4.0 0.8 1.0
C A:VAL355 4.0 0.5 1.0
C A:ARG276 4.1 0.6 1.0
C A:PRO356 4.1 0.7 1.0
CB A:THR398 4.1 0.8 1.0
CG2 A:THR398 4.3 0.6 1.0
O A:ASP394 4.3 0.5 1.0
CA A:PRO356 4.4 0.1 1.0
NE A:ARG397 4.5 0.2 1.0
OD1 A:ASP394 4.5 0.0 1.0
C A:ALA353 4.6 0.5 1.0
CA A:THR398 4.7 0.8 1.0
N A:PRO356 4.7 0.1 1.0
N A:THR398 4.7 0.7 1.0
CA A:ARG276 4.7 0.5 1.0
N A:GLY354 4.8 0.3 1.0
N A:ALA358 4.9 0.4 1.0
CB A:ARG276 4.9 0.4 1.0
CG1 A:VAL355 4.9 1.0 1.0

Thallium binding site 3 out of 6 in 4p1a

Go back to Thallium Binding Sites List in 4p1a
Thallium binding site 3 out of 6 in the Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 3 of Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Tl501

b:1.0
occ:0.80
 O B:THR308 2.8 0.6 1.0
O B:SER349 3.1 0.9 1.0
O B:ASN310 3.5 0.7 1.0
N B:GLY351 3.6 0.6 1.0
CA B:ILE350 3.7 0.3 1.0
C B:ILE309 3.7 0.1 1.0
O B:ILE309 3.7 0.3 1.0
N B:ALA353 3.7 0.1 1.0
C B:SER349 3.7 0.3 1.0
N B:THR352 3.7 0.3 1.0
CA B:ILE309 3.9 0.5 1.0
C B:ASN310 3.9 1.0 1.0
C B:THR308 3.9 0.5 1.0
CA B:ALA353 4.0 0.4 1.0
OG B:SER349 4.0 0.3 1.0
N B:ILE350 4.0 0.2 1.0
CB B:ALA353 4.0 1.0 1.0
C B:ILE350 4.1 0.6 1.0
CG B:MET311 4.1 0.4 1.0
N B:ASN310 4.2 0.1 1.0
C B:THR352 4.2 0.1 1.0
CA B:MET311 4.2 0.2 1.0
N B:MET311 4.4 0.4 1.0
N B:ILE309 4.4 0.5 1.0
CA B:THR352 4.5 0.5 1.0
C B:GLY351 4.6 0.0 1.0
CA B:GLY351 4.6 0.6 1.0
CA B:ASN310 4.6 0.8 1.0
CB B:SER349 4.7 0.9 1.0
CB B:MET311 4.7 0.9 1.0
OG1 B:THR352 4.7 0.6 1.0
CB B:ILE350 4.8 0.8 1.0
CA B:SER349 4.8 0.9 1.0
OG1 B:THR314 4.9 0.2 1.0
O B:THR352 4.9 0.5 1.0

Thallium binding site 4 out of 6 in 4p1a

Go back to Thallium Binding Sites List in 4p1a
Thallium binding site 4 out of 6 in the Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 4 of Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Tl502

b:0.8
occ:0.80
 OD2 B:ASP394 2.7 0.2 1.0
OG1 B:THR398 2.9 0.3 1.0
O B:ARG276 3.0 0.9 1.0
O B:VAL355 3.0 0.3 1.0
O B:PRO356 3.1 0.2 1.0
NH2 B:ARG397 3.4 0.7 1.0
CZ B:ARG397 3.6 0.2 1.0
NH1 B:ARG397 3.7 0.3 1.0
O B:ALA353 3.8 0.8 1.0
CG B:ASP394 3.9 1.0 1.0
CB B:THR398 4.1 0.1 1.0
C B:PRO356 4.1 0.8 1.0
CA B:GLY354 4.1 0.3 1.0
C B:ARG276 4.1 0.7 1.0
O B:ASP394 4.2 0.0 1.0
C B:VAL355 4.2 0.6 1.0
CG2 B:THR398 4.3 0.1 1.0
NE B:ARG397 4.4 0.6 1.0
OD1 B:ASP394 4.4 0.3 1.0
CA B:PRO356 4.5 0.1 1.0
CA B:THR398 4.6 0.4 1.0
N B:THR398 4.6 0.8 1.0
CA B:ARG276 4.8 0.2 1.0
C B:ALA353 4.8 0.2 1.0
N B:PRO356 4.8 0.1 1.0
CB B:ARG276 4.8 1.0 1.0
N B:ALA358 4.9 0.1 1.0
CB B:ASP394 5.0 0.7 1.0
N B:GLY354 5.0 0.3 1.0

Thallium binding site 5 out of 6 in 4p1a

Go back to Thallium Binding Sites List in 4p1a
Thallium binding site 5 out of 6 in the Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 5 of Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Tl501

b:0.4
occ:0.50
 O C:SER349 2.9 0.9 1.0
O C:ASN310 3.1 0.7 1.0
O C:THR308 3.2 1.0 1.0
C C:SER349 3.6 0.7 1.0
N C:ALA353 3.7 0.6 1.0
OG C:SER349 3.7 0.4 1.0
O C:ILE309 3.7 0.8 1.0
C C:ASN310 3.7 0.8 1.0
CA C:ALA353 3.8 0.0 1.0
C C:ILE309 3.9 0.6 1.0
CA C:ILE350 3.9 0.2 1.0
N C:THR352 3.9 0.3 1.0
CA C:MET311 4.0 0.1 1.0
N C:GLY351 4.0 0.2 1.0
CB C:ALA353 4.0 0.5 1.0
CG C:MET311 4.1 0.4 1.0
N C:ILE350 4.1 0.1 1.0
C C:THR352 4.1 0.7 1.0
N C:MET311 4.2 0.8 1.0
CA C:ILE309 4.3 0.9 1.0
C C:THR308 4.3 0.3 1.0
N C:ASN310 4.4 0.5 1.0
OG1 C:THR314 4.4 0.3 1.0
C C:ILE350 4.4 1.0 1.0
CB C:SER349 4.5 0.9 1.0
CA C:THR352 4.5 1.0 1.0
CB C:MET311 4.6 0.7 1.0
OG1 C:THR352 4.6 0.9 1.0
CA C:ASN310 4.7 0.3 1.0
CA C:SER349 4.7 0.2 1.0
O C:THR352 4.8 0.3 1.0
N C:ILE309 4.8 0.9 1.0
C C:GLY351 4.9 0.4 1.0
CA C:GLY351 5.0 0.2 1.0

Thallium binding site 6 out of 6 in 4p1a

Go back to Thallium Binding Sites List in 4p1a
Thallium binding site 6 out of 6 in the Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 6 of Thallium-Bound Inward-Facing State of the Glutamate Transporter Homologue Gltph within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Tl502

b:0.9
occ:0.50
 OD2 C:ASP394 2.3 0.1 1.0
OG1 C:THR398 2.7 0.6 1.0
O C:PRO356 3.0 1.0 1.0
O C:ARG276 3.2 0.3 1.0
NH2 C:ARG397 3.2 0.7 1.0
O C:VAL355 3.4 0.1 1.0
CG C:ASP394 3.4 0.9 1.0
CZ C:ARG397 3.4 0.2 1.0
NH1 C:ARG397 3.6 0.1 1.0
O C:ASP394 3.7 0.7 1.0
CB C:THR398 4.0 0.2 1.0
OD1 C:ASP394 4.0 0.6 1.0
O C:ALA353 4.1 0.1 1.0
C C:PRO356 4.1 0.7 1.0
NE C:ARG397 4.1 0.7 1.0
C C:ARG276 4.3 0.0 1.0
N C:THR398 4.3 0.1 1.0
CG2 C:THR398 4.4 0.7 1.0
CA C:THR398 4.5 0.0 1.0
CB C:ASP394 4.5 0.1 1.0
C C:VAL355 4.6 1.0 1.0
CA C:GLY354 4.6 0.5 1.0
C C:ASP394 4.7 1.0 1.0
CB C:ARG397 4.7 0.5 1.0
CA C:PRO356 4.7 0.1 1.0
CB C:ARG276 4.7 0.1 1.0
CA C:ARG276 4.8 0.5 1.0
CA C:ASP394 4.8 0.5 1.0
N C:ALA358 4.9 0.7 1.0
CD C:ARG397 5.0 0.1 1.0

Reference:

G.Verdon, S.Oh, R.N.Serio, O.Boudker. Coupled Ion Binding and Structural Transitions Along the Transport Cycle of Glutamate Transporters. Elife V. 3 02283 2014.
ISSN: ESSN 2050-084X
PubMed: 24842876
DOI: 10.7554/ELIFE.02283
Page generated: Fri Oct 11 10:02:13 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy