Atomistry » Thallium » PDB 1f1h-4wfh » 4p6h
Atomistry »
  Thallium »
    PDB 1f1h-4wfh »
      4p6h »

Thallium in PDB 4p6h: Tl+-Bound Inward-Facing State (Bound Conformation) of the Glutamate Transporter Homologue Gltph

Protein crystallography data

The structure of Tl+-Bound Inward-Facing State (Bound Conformation) of the Glutamate Transporter Homologue Gltph, PDB code: 4p6h was solved by G.Verdon, O.Boudker, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 4.08
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 110.830, 200.434, 206.397, 90.00, 90.00, 90.00
R / Rfree (%) 25.8 / 29.6

Other elements in 4p6h:

The structure of Tl+-Bound Inward-Facing State (Bound Conformation) of the Glutamate Transporter Homologue Gltph also contains other interesting chemical elements:

Mercury (Hg) 3 atoms

Thallium Binding Sites:

The binding sites of Thallium atom in the Tl+-Bound Inward-Facing State (Bound Conformation) of the Glutamate Transporter Homologue Gltph (pdb code 4p6h). This binding sites where shown within 5.0 Angstroms radius around Thallium atom.
In total 6 binding sites of Thallium where determined in the Tl+-Bound Inward-Facing State (Bound Conformation) of the Glutamate Transporter Homologue Gltph, PDB code: 4p6h:
Jump to Thallium binding site number: 1; 2; 3; 4; 5; 6;

Thallium binding site 1 out of 6 in 4p6h

Go back to Thallium Binding Sites List in 4p6h
Thallium binding site 1 out of 6 in the Tl+-Bound Inward-Facing State (Bound Conformation) of the Glutamate Transporter Homologue Gltph


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 1 of Tl+-Bound Inward-Facing State (Bound Conformation) of the Glutamate Transporter Homologue Gltph within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Tl502

b:91.5
occ:0.80
 O A:GLY306 2.3 0.3 1.0
OD2 A:ASP405 2.6 0.4 1.0
O A:ASN310 2.7 0.1 1.0
OD1 A:ASP405 2.9 0.9 1.0
CG A:ASP405 3.1 0.9 1.0
O A:ASN401 3.1 0.9 1.0
C A:GLY306 3.4 0.6 1.0
C A:ASN401 3.5 0.4 1.0
CB A:ASN401 3.6 0.1 1.0
CG A:MET311 3.7 99.8 1.0
O A:ILE309 3.7 0.4 1.0
C A:ASN310 3.7 0.6 1.0
CA A:ALA307 3.8 0.1 1.0
CA A:ASN401 3.9 0.7 1.0
C A:ALA307 3.9 0.5 1.0
O A:ALA307 3.9 0.1 1.0
OG A:SER278 4.0 0.7 1.0
N A:ALA307 4.0 0.2 1.0
CA A:MET311 4.1 0.2 1.0
N A:MET311 4.3 0.2 1.0
N A:VAL402 4.4 0.4 1.0
ND2 A:ASN310 4.4 1.0 1.0
CB A:MET311 4.5 99.8 1.0
CG A:ASN401 4.6 0.6 1.0
N A:THR308 4.6 0.3 1.0
CA A:GLY306 4.6 0.7 1.0
CB A:ASP405 4.7 0.3 1.0
C A:ILE309 4.7 0.0 1.0
CA A:ASN310 4.9 0.2 1.0
CB A:ASN310 4.9 0.4 1.0
SD A:MET311 4.9 97.2 1.0
CA A:VAL402 4.9 0.6 1.0

Thallium binding site 2 out of 6 in 4p6h

Go back to Thallium Binding Sites List in 4p6h
Thallium binding site 2 out of 6 in the Tl+-Bound Inward-Facing State (Bound Conformation) of the Glutamate Transporter Homologue Gltph


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 2 of Tl+-Bound Inward-Facing State (Bound Conformation) of the Glutamate Transporter Homologue Gltph within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Tl503

b:0.6
occ:0.40
 O A:THR352 2.0 0.2 1.0
O A:THR308 2.1 0.2 1.0
O A:SER349 2.3 0.7 1.0
C A:THR308 2.9 0.6 1.0
C A:THR352 3.0 0.5 1.0
C A:SER349 3.3 0.3 1.0
N A:THR352 3.3 99.9 1.0
C A:GLY351 3.5 0.9 1.0
CA A:THR352 3.5 99.1 1.0
O A:GLY351 3.5 0.5 1.0
C A:ILE350 3.6 0.1 1.0
N A:ILE309 3.7 0.8 1.0
O A:ILE350 3.7 0.0 1.0
CA A:THR308 3.8 0.6 1.0
CA A:ILE350 3.8 0.5 1.0
CB A:THR352 3.8 97.3 1.0
CA A:ILE309 3.9 0.7 1.0
N A:GLY351 3.9 0.0 1.0
N A:ILE350 3.9 0.1 1.0
SD A:MET311 4.1 97.2 1.0
N A:ALA353 4.1 0.3 1.0
CB A:THR308 4.3 0.1 1.0
CA A:GLY351 4.3 0.8 1.0
CA A:SER349 4.3 99.3 1.0
CG A:MET311 4.4 99.8 1.0
OG1 A:THR352 4.4 96.3 1.0
CA A:ALA353 4.6 0.0 1.0
C A:ILE309 4.9 0.0 1.0
OG A:SER349 4.9 0.7 1.0
CB A:ILE309 4.9 0.7 1.0

Thallium binding site 3 out of 6 in 4p6h

Go back to Thallium Binding Sites List in 4p6h
Thallium binding site 3 out of 6 in the Tl+-Bound Inward-Facing State (Bound Conformation) of the Glutamate Transporter Homologue Gltph


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 3 of Tl+-Bound Inward-Facing State (Bound Conformation) of the Glutamate Transporter Homologue Gltph within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Tl502

b:85.8
occ:0.80
 O B:GLY306 2.3 0.6 1.0
OD2 B:ASP405 2.6 0.6 1.0
O B:ASN310 2.7 99.2 1.0
OD1 B:ASP405 2.9 0.3 1.0
CG B:ASP405 3.1 0.6 1.0
O B:ASN401 3.1 0.6 1.0
C B:GLY306 3.4 0.3 1.0
C B:ASN401 3.5 0.9 1.0
CB B:ASN401 3.6 0.0 1.0
CG B:MET311 3.7 87.6 1.0
O B:ILE309 3.7 96.4 1.0
C B:ASN310 3.7 95.7 1.0
CA B:ALA307 3.8 0.3 1.0
C B:ALA307 3.9 99.2 1.0
CA B:ASN401 3.9 0.1 1.0
O B:ALA307 3.9 96.8 1.0
OG B:SER278 4.0 0.7 1.0
N B:ALA307 4.0 0.8 1.0
CA B:MET311 4.1 90.9 1.0
N B:MET311 4.3 91.2 1.0
N B:VAL402 4.4 1.0 1.0
ND2 B:ASN310 4.4 0.1 1.0
CB B:MET311 4.5 86.6 1.0
CG B:ASN401 4.6 98.4 1.0
N B:THR308 4.6 97.3 1.0
CA B:GLY306 4.6 1.0 1.0
CB B:ASP405 4.7 0.7 1.0
C B:ILE309 4.7 93.2 1.0
CA B:ASN310 4.9 96.8 1.0
CB B:ASN310 4.9 0.9 1.0
SD B:MET311 4.9 84.1 1.0
CA B:VAL402 4.9 0.8 1.0

Thallium binding site 4 out of 6 in 4p6h

Go back to Thallium Binding Sites List in 4p6h
Thallium binding site 4 out of 6 in the Tl+-Bound Inward-Facing State (Bound Conformation) of the Glutamate Transporter Homologue Gltph


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 4 of Tl+-Bound Inward-Facing State (Bound Conformation) of the Glutamate Transporter Homologue Gltph within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Tl503

b:100.0
occ:0.40
 O B:THR352 2.0 83.2 1.0
O B:THR308 2.1 86.5 1.0
O B:SER349 2.3 79.9 1.0
C B:THR308 2.9 89.6 1.0
C B:THR352 3.0 81.8 1.0
C B:SER349 3.3 77.5 1.0
N B:THR352 3.3 75.9 1.0
C B:GLY351 3.5 76.6 1.0
CA B:THR352 3.5 77.8 1.0
O B:GLY351 3.5 79.0 1.0
C B:ILE350 3.6 77.7 1.0
N B:ILE309 3.7 91.4 1.0
O B:ILE350 3.7 79.7 1.0
CA B:THR308 3.8 92.3 1.0
CA B:ILE350 3.8 78.6 1.0
CB B:THR352 3.8 77.7 1.0
CA B:ILE309 3.9 90.1 1.0
N B:GLY351 3.9 75.1 1.0
N B:ILE350 3.9 76.8 1.0
SD B:MET311 4.1 84.1 1.0
N B:ALA353 4.1 84.5 1.0
CB B:THR308 4.3 93.2 1.0
CA B:GLY351 4.3 75.0 1.0
CA B:SER349 4.3 76.0 1.0
CG B:MET311 4.4 87.6 1.0
OG1 B:THR352 4.4 75.0 1.0
CA B:ALA353 4.6 89.4 1.0
C B:ILE309 4.9 93.2 1.0
OG B:SER349 4.9 82.7 1.0
CB B:ILE309 4.9 91.7 1.0

Thallium binding site 5 out of 6 in 4p6h

Go back to Thallium Binding Sites List in 4p6h
Thallium binding site 5 out of 6 in the Tl+-Bound Inward-Facing State (Bound Conformation) of the Glutamate Transporter Homologue Gltph


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 5 of Tl+-Bound Inward-Facing State (Bound Conformation) of the Glutamate Transporter Homologue Gltph within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Tl502

b:0.3
occ:0.80
 O C:GLY306 2.3 0.4 1.0
OD2 C:ASP405 2.6 0.5 1.0
O C:ASN310 2.7 0.5 1.0
OD1 C:ASP405 2.9 0.9 1.0
CG C:ASP405 3.1 0.1 1.0
O C:ASN401 3.1 0.2 1.0
C C:GLY306 3.4 0.2 1.0
C C:ASN401 3.5 0.4 1.0
CB C:ASN401 3.6 0.7 1.0
CG C:MET311 3.7 0.2 1.0
O C:ILE309 3.7 0.3 1.0
C C:ASN310 3.7 0.9 1.0
CA C:ALA307 3.8 0.0 1.0
C C:ALA307 3.9 0.8 1.0
CA C:ASN401 3.9 0.5 1.0
O C:ALA307 3.9 0.8 1.0
OG C:SER278 4.0 1.0 1.0
N C:ALA307 4.0 0.3 1.0
CA C:MET311 4.1 0.0 1.0
N C:MET311 4.3 0.1 1.0
N C:VAL402 4.4 0.1 1.0
ND2 C:ASN310 4.4 0.6 1.0
CB C:MET311 4.5 0.7 1.0
CG C:ASN401 4.6 0.4 1.0
N C:THR308 4.6 0.2 1.0
CA C:GLY306 4.6 0.0 1.0
CB C:ASP405 4.7 0.1 1.0
C C:ILE309 4.7 0.1 1.0
CA C:ASN310 4.9 0.9 1.0
CB C:ASN310 4.9 0.5 1.0
CA C:VAL402 4.9 0.8 1.0
SD C:MET311 4.9 0.4 1.0

Thallium binding site 6 out of 6 in 4p6h

Go back to Thallium Binding Sites List in 4p6h
Thallium binding site 6 out of 6 in the Tl+-Bound Inward-Facing State (Bound Conformation) of the Glutamate Transporter Homologue Gltph


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 6 of Tl+-Bound Inward-Facing State (Bound Conformation) of the Glutamate Transporter Homologue Gltph within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Tl503

b:0.9
occ:0.40
 O C:THR352 2.0 0.6 1.0
O C:THR308 2.1 0.6 1.0
O C:SER349 2.3 0.5 1.0
C C:THR308 2.9 0.6 1.0
C C:THR352 3.0 0.9 1.0
C C:SER349 3.3 0.5 1.0
N C:THR352 3.3 0.8 1.0
C C:GLY351 3.4 0.4 1.0
CA C:THR352 3.5 0.7 1.0
O C:GLY351 3.5 0.9 1.0
C C:ILE350 3.6 0.2 1.0
N C:ILE309 3.7 0.1 1.0
O C:ILE350 3.7 0.9 1.0
CA C:THR308 3.8 0.8 1.0
CA C:ILE350 3.8 0.8 1.0
CB C:THR352 3.8 0.7 1.0
CA C:ILE309 3.9 0.2 1.0
N C:GLY351 3.9 0.1 1.0
N C:ILE350 3.9 0.5 1.0
SD C:MET311 4.1 0.4 1.0
N C:ALA353 4.1 0.2 1.0
CB C:THR308 4.3 0.7 1.0
CA C:GLY351 4.3 0.9 1.0
CA C:SER349 4.3 0.6 1.0
CG C:MET311 4.4 0.2 1.0
OG1 C:THR352 4.4 0.3 1.0
CA C:ALA353 4.6 0.0 1.0
C C:ILE309 4.9 0.1 1.0
OG C:SER349 4.9 0.5 1.0
CB C:ILE309 4.9 0.4 1.0

Reference:

G.Verdon, S.Oh, R.N.Serio, O.Boudker. Coupled Ion Binding and Structural Transitions Along the Transport Cycle of Glutamate Transporters. Elife V. 3 02283 2014.
ISSN: ESSN 2050-084X
PubMed: 24842876
DOI: 10.7554/ELIFE.02283
Page generated: Wed Dec 16 02:28:48 2020

Last articles

Zn in 7OQY
Zn in 7PEL
Zn in 7OYG
Zn in 7P3S
Zn in 7PE7
Zn in 7RZC
Zn in 7PE9
Zn in 7PE8
Zn in 7RAG
Zn in 7RN5
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy