Atomistry » Thallium » PDB 5avq-8vnu » 7lja
Atomistry »
  Thallium »
    PDB 5avq-8vnu »
      7lja »

Thallium in PDB 7lja: Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation

Protein crystallography data

The structure of Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation, PDB code: 7lja was solved by R.A.Rietmeijer, S.G.Brohawn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.54 / 2.77
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 80.23, 136.53, 95.28, 90, 94.54, 90
R / Rfree (%) 20.1 / 24.3

Other elements in 7lja:

The structure of Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation also contains other interesting chemical elements:

Calcium (Ca) 3 atoms

Thallium Binding Sites:

The binding sites of Thallium atom in the Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation (pdb code 7lja). This binding sites where shown within 5.0 Angstroms radius around Thallium atom.
In total 8 binding sites of Thallium where determined in the Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation, PDB code: 7lja:
Jump to Thallium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Thallium binding site 1 out of 8 in 7lja

Go back to Thallium Binding Sites List in 7lja
Thallium binding site 1 out of 8 in the Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 1 of Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Tl301

b:85.7
occ:1.00
 O B:VAL239 2.4 74.0 1.0
O A:ILE130 2.7 74.2 1.0
O A:THR238 2.7 75.5 1.0
O B:ILE130 2.7 73.9 1.0
O A:VAL239 2.8 74.4 1.0
O A:THR129 2.8 81.8 1.0
O B:THR238 2.8 77.3 1.0
O B:THR129 2.9 79.3 1.0
TL A:TL305 3.2 88.1 1.0
C B:VAL239 3.3 73.5 1.0
C A:VAL239 3.5 74.7 1.0
C A:ILE130 3.5 74.7 1.0
TL A:TL302 3.5 88.4 1.0
C B:ILE130 3.6 75.9 1.0
C A:THR238 3.8 76.1 1.0
CA B:VAL239 3.8 72.9 1.0
C B:THR238 3.9 75.5 1.0
C A:THR129 3.9 79.2 1.0
CA A:VAL239 3.9 75.0 1.0
C B:THR129 4.0 80.4 1.0
CA A:ILE130 4.1 76.1 1.0
CA B:ILE130 4.2 77.4 1.0
N B:GLY240 4.3 73.6 1.0
N B:VAL239 4.3 73.3 1.0
N A:VAL239 4.3 75.3 1.0
N A:ILE130 4.4 77.8 1.0
N A:GLY240 4.4 74.9 1.0
N A:GLY131 4.5 74.3 1.0
N B:ILE130 4.6 79.6 1.0
N B:GLY131 4.6 77.5 1.0
CA B:GLY240 4.6 75.3 1.0
O B:GLY240 4.7 76.2 1.0
CA A:GLY240 4.8 75.5 1.0
O A:GLY240 4.8 75.3 1.0
CA A:GLY131 4.9 73.9 1.0
OG1 B:THR238 4.9 76.2 1.0
O A:GLY131 4.9 72.7 1.0
O B:GLY131 4.9 80.2 1.0
CA B:GLY131 4.9 78.9 1.0
C B:GLY240 4.9 75.1 1.0

Thallium binding site 2 out of 8 in 7lja

Go back to Thallium Binding Sites List in 7lja
Thallium binding site 2 out of 8 in the Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 2 of Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Tl302

b:88.4
occ:1.00
 OG1 B:THR238 2.5 76.2 1.0
OG1 A:THR238 2.5 77.1 1.0
O A:THR238 2.7 75.5 1.0
O A:THR129 2.8 81.8 1.0
O B:THR238 2.8 77.3 1.0
OG1 A:THR129 2.8 80.3 1.0
O B:THR129 2.9 79.3 1.0
OG1 B:THR129 2.9 80.6 1.0
CB A:THR238 3.4 78.6 1.0
CB B:THR238 3.5 77.7 1.0
CB A:THR129 3.5 79.9 1.0
TL A:TL301 3.5 85.7 1.0
CB B:THR129 3.6 81.9 1.0
C A:THR238 3.7 76.1 1.0
C A:THR129 3.7 79.2 1.0
C B:THR238 3.7 75.5 1.0
C B:THR129 3.8 80.4 1.0
CA A:THR238 4.2 77.8 1.0
CA A:THR129 4.3 79.7 1.0
CA B:THR238 4.3 76.6 1.0
CA B:THR129 4.4 81.5 1.0
CG2 A:THR238 4.6 80.4 1.0
CG2 B:THR238 4.7 78.6 1.0
N B:VAL239 4.7 73.3 1.0
N A:VAL239 4.7 75.3 1.0
N A:ILE130 4.7 77.8 1.0
CG2 A:THR129 4.8 80.4 1.0
N B:ILE130 4.8 79.6 1.0
O A:THR237 4.8 79.0 1.0
O B:THR237 4.9 74.9 1.0
CG2 B:THR129 4.9 83.5 1.0
CA B:VAL239 5.0 72.9 1.0

Thallium binding site 3 out of 8 in 7lja

Go back to Thallium Binding Sites List in 7lja
Thallium binding site 3 out of 8 in the Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 3 of Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Tl305

b:88.1
occ:1.00
 O B:GLY240 2.4 76.2 1.0
O A:GLY240 2.6 75.3 1.0
O A:GLY131 2.7 72.7 1.0
O B:GLY131 2.8 80.2 1.0
O A:VAL239 2.8 74.4 1.0
O B:VAL239 2.9 74.0 1.0
O A:ILE130 3.0 74.2 1.0
TL A:TL301 3.2 85.7 1.0
O B:ILE130 3.2 73.9 1.0
TL B:TL301 3.2 89.6 1.0
C B:GLY240 3.3 75.1 1.0
C A:GLY240 3.4 74.8 1.0
C A:GLY131 3.5 73.0 1.0
C B:GLY131 3.6 79.3 1.0
C A:VAL239 3.9 74.7 1.0
C B:VAL239 4.0 73.5 1.0
CA B:GLY240 4.0 75.3 1.0
CA A:GLY240 4.1 75.5 1.0
C A:ILE130 4.1 74.7 1.0
N B:PHE241 4.2 74.2 1.0
CA A:GLY131 4.2 73.9 1.0
C B:ILE130 4.3 75.9 1.0
CA B:GLY131 4.3 78.9 1.0
N A:PHE241 4.3 73.9 1.0
O A:PHE241 4.4 76.6 1.0
N B:GLY240 4.4 73.6 1.0
N A:TYR132 4.4 73.4 1.0
N A:GLY240 4.5 74.9 1.0
N B:TYR132 4.5 80.8 1.0
CA A:PHE241 4.6 74.4 1.0
CA B:PHE241 4.6 75.9 1.0
N A:GLY131 4.6 74.3 1.0
O B:TYR132 4.7 84.0 1.0
O A:TYR132 4.7 76.5 1.0
O B:PHE241 4.7 80.0 1.0
CA A:TYR132 4.7 73.4 1.0
CA B:TYR132 4.7 80.5 1.0
N B:GLY131 4.8 77.5 1.0
C A:PHE241 4.8 76.2 1.0
C B:PHE241 4.8 78.8 1.0
C B:TYR132 4.9 81.8 1.0
C A:TYR132 4.9 74.0 1.0

Thallium binding site 4 out of 8 in 7lja

Go back to Thallium Binding Sites List in 7lja
Thallium binding site 4 out of 8 in the Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 4 of Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation within 5.0Å range:

Thallium binding site 5 out of 8 in 7lja

Go back to Thallium Binding Sites List in 7lja
Thallium binding site 5 out of 8 in the Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 5 of Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Tl307

b:225.3
occ:1.00
 O A:TRP223 2.5 113.7 1.0
O A:CYS218 2.8 126.0 1.0
SG A:CYS218 3.1 123.6 1.0
C A:CYS218 3.5 124.6 1.0
C A:TRP223 3.6 108.6 1.0
CA A:CYS218 3.9 121.3 1.0
CB A:CYS218 4.1 122.1 1.0
N A:TRP223 4.1 108.9 1.0
C A:ASP222 4.3 112.9 1.0
N A:SER224 4.3 108.7 1.0
CA A:SER224 4.4 112.2 1.0
CA A:TRP223 4.5 105.0 1.0
CA A:ASP222 4.5 118.0 1.0
N A:TYR219 4.6 126.8 1.0
OD1 A:ASP222 4.8 130.3 1.0
O A:ASP222 4.8 111.9 1.0

Thallium binding site 6 out of 8 in 7lja

Go back to Thallium Binding Sites List in 7lja
Thallium binding site 6 out of 8 in the Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 6 of Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Tl301

b:89.6
occ:1.00
 O A:PHE241 2.4 76.6 1.0
O B:PHE241 2.5 80.0 1.0
O B:TYR132 2.5 84.0 1.0
O A:TYR132 2.6 76.5 1.0
O B:GLY240 3.1 76.2 1.0
TL A:TL305 3.2 88.1 1.0
O A:GLY240 3.3 75.3 1.0
O A:GLY131 3.3 72.7 1.0
C B:PHE241 3.4 78.8 1.0
C A:PHE241 3.4 76.2 1.0
O B:GLY131 3.4 80.2 1.0
C B:TYR132 3.4 81.8 1.0
C A:TYR132 3.5 74.0 1.0
CA B:PHE241 4.0 75.9 1.0
CA A:PHE241 4.1 74.4 1.0
C B:GLY240 4.1 75.1 1.0
CA B:TYR132 4.2 80.5 1.0
N B:GLY133 4.3 84.5 1.0
CA A:TYR132 4.3 73.4 1.0
N B:GLY242 4.3 80.7 1.0
C A:GLY240 4.3 74.8 1.0
N A:GLY133 4.4 74.3 1.0
C A:GLY131 4.4 73.0 1.0
N A:GLY242 4.4 78.0 1.0
C B:GLY131 4.5 79.3 1.0
CA B:GLY133 4.5 85.0 1.0
N B:PHE241 4.5 74.2 1.0
CA A:GLY133 4.5 74.0 1.0
N A:PHE241 4.7 73.9 1.0
CA B:GLY242 4.7 85.2 1.0
CA A:GLY242 4.8 80.5 1.0
N B:TYR132 4.8 80.8 1.0
N A:TYR132 4.8 73.4 1.0

Thallium binding site 7 out of 8 in 7lja

Go back to Thallium Binding Sites List in 7lja
Thallium binding site 7 out of 8 in the Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 7 of Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Tl302

b:183.2
occ:1.00
 O B:HOH429 3.2 66.8 1.0
O B:HOH424 3.3 57.0 1.0
O B:HOH430 3.7 92.0 1.0
O A:HOH430 3.8 55.0 1.0
O B:HOH433 3.9 62.1 1.0
O B:HOH434 4.2 60.7 1.0

Thallium binding site 8 out of 8 in 7lja

Go back to Thallium Binding Sites List in 7lja
Thallium binding site 8 out of 8 in the Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation


Mono view


Stereo pair view

A full contact list of Thallium with other atoms in the Tl binding site number 8 of Human Traak K+ Channel Fheig Mutant A198E in A Tl+ Bound Conductive Conformation within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Tl303

b:245.4
occ:1.00
 O B:TRP223 2.4 106.6 1.0
O B:CYS218 2.5 112.9 1.0
C B:CYS218 3.5 112.3 1.0
SG B:CYS218 3.5 111.4 1.0
C B:TRP223 3.6 100.7 1.0
N B:TRP223 3.8 101.6 1.0
CA B:CYS218 3.9 109.7 1.0
C B:ASP222 4.0 105.0 1.0
CA B:ASP222 4.0 109.5 1.0
OD1 B:ASP222 4.1 112.3 1.0
CB B:CYS218 4.2 110.7 1.0
CA B:TRP223 4.4 97.9 1.0
N B:TYR219 4.5 114.4 1.0
N B:SER224 4.5 100.1 1.0
O B:ASP222 4.6 104.6 1.0
CA B:SER224 4.7 101.1 1.0
N B:ASP222 4.8 109.5 1.0
CA B:TYR219 5.0 118.6 1.0

Reference:

R.A.Rietmeijer, B.Sorum, B.Li, S.G.Brohawn. Physical Basis For Distinct Basal and Mechanically-Gated Activity of the Human K + Channel Traak Biorxiv 2021.
DOI: 10.1101/2021.06.04.447000
Page generated: Fri Oct 11 10:24:40 2024

Last articles

Zn in 9J0N
Zn in 9J0O
Zn in 9J0P
Zn in 9FJX
Zn in 9EKB
Zn in 9C0F
Zn in 9CAH
Zn in 9CH0
Zn in 9CH3
Zn in 9CH1
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy